Length of Treatment

Length of Treatment for Hepatitis C, Life Beyond Hepatitis C

Length of treatment

Standard length of treatment is 12 to 24 weeks, depending on genotype, viral load, liver condition and prior treatment experience and response. In some cases, 8 weeks may be considered in patients without cirrhosis who have pre-treatment HCV RNA (viral load count) less than 6 million IU/mL.

The treatment timeline will depend on your HCV-RNA (virus load count), SVR (sustained virologic response) meaning if the virus is detected in your blood over a period of time, your liver condition, and severity of side effects.

 

 

For treatment with Epclusa, Vosevi, or Mavyret; These treatments work for all genotypes 1-6:

Standard treatment time is 12 weeks.

 

For Genotype 1a:

Epclusa for 12 weeks

or

Vosevi for 12 weeks

or

Mavyret for 12 weeks**

or

Harvoni for 12 weeks**

or

Olysio + Sovaldi with or without Ribavirin for 12 weeks (w/o cirrhosis) or 24 weeks (with cirrhosis)

or

Viekira Pak + Ribavirin for 12 weeks (w/o cirrhosis) or 24 weeks (with cirrhosis)

or

Daklinza for 12 weeks

or

Zepatier for 12 weeks

 

For Genotype 1b:

Epclusa for 12 weeks

or

Vosevi for 12 weeks

or

Mavyret for 12 weeks**

or

Harvoni for 12 weeks**

or

Olysio + Sovaldi for 12 weeks (w/o cirrhosis) or 24 weeks (with cirrhosis)

or

Viekira Pak for 12 weeks (w/o cirrhosis) or use with Ribavirin for 12 weeks (with cirrhosis)

or

Daklinza for 12 weeks

or

Zepatier for 12 weeks

 

For Genotype 2:

Epclusa for 12 weeks

or

Vosevi for 12 weeks

or

Mavyret for 12 weeks**

or

Sovaldi + Ribavirin for 12 to 16 weeks (with cirrhosis)

 

For Genotype 3:

Epclusa for 12 weeks

or

Vosevi for 12 weeks

or

Mavyret for 12 weeks**

or

Sovaldi + Ribavirin for 24 weeks

Or

Daklinza (Daclastavir+ Sofosbuvir) Bristol- Myers Squibb (BMS)  without Ribavirin for 12 weeks

 

 

For Genotype 4:

Epclusa for 12 weeks

or

Vosevi for 12 weeks

or

Mavyret for 12 weeks**

or

Harvoni for 12 weeks

Or

Viekira Pak (without Dasabuvir) + Ribavirin for 12 weeks

Or

Technivie (ombitasvir, paritaprevir and ritonavir) + with or without Ribavirin for 12 weeks

Or

Sovaldi + Ribavirin for 24 weeks

or

Zepatier with or without Ribavirin for 12 weeks

 

 

For Genotype 5:

Epclusa for 12 weeks

or

Vosevi for 12 weeks

or

Mavyret for 12 weeks**

or

Harvoni for 12 weeks

or

Sovaldi + Ribavirin + Peg Interferon for 12 weeks

 

For Genotype 6:

Epclusa for 12 weeks

or

Vosevi for 12 weeks

or

Mavyret for 12 weeks**

or

Harvoni for 12 weeks

 

**denotes 8 weeks of treatment may be considered in patients without cirrhosis who have pre-treatment viral load (RNA) less than 6 million/IUmL

The above treatment and duration recommendations for all genotypes are from the Amercian Association for the Study of Liver Disease (AASLD) and the Infectious Disease Society of American (IDSA).

 

Blood tests are generally done every 4 weeks throughout treatment to check your viral load and blood levels.

Important to Remember

It’s important to know and have confidence in your treatment.  These medications have gone through extensive clinical research and trials and have proved to be effective.  Be patient with this process.  Your journey to health is worth it.

Before Treatment Begins

Preparation time typically takes 4 weeks prior to beginning treatment.  Your doctor will order baseline tests to be done prior to beginning treatment.

UT Southwestern Clinical Center for Liver Disease states it typically takes four weeks to get insurance approval and receive the medications. Even if you have given interferon injections and taken ribivarin in the past, you must attend the nurse teaching session based on the dosing schedule, and receive information on drug interactions and side effects. Patients can receive their first dose at the end of the mandatory nurse teaching session.

If possible, it is good to take a family member or friend with you to the teaching session, write down your questions and the answers.  They can help support you and also learn what to expect with the treatment.  You have a big support team with your doctors, nurses, medical staff, family and friends.  Additional resources are also available for you to get the help you need.

 

References

Epclusa, made by Gilead Sciences

Harvoni, made by Gilead Sciences

Olysio, made by Janssen and Olysio/Sovaldi Combo

Sovaldi made by Gilead Sciences

Viekira Pak made by AbbVie

Daklinza by Bristol-Myers Squibb (BMS)

Technivie by AbbVie

Merck, makers of Zepatier

UT Southwestern Clinical Center for Liver Disease 

Mayo Clinic 

Center for Disease Control & Prevention 

American Liver Foundation 

Hepatitis Foundation International 

 

See Resource & Support Listings for additional references and help.