Extrahepatic Manifestations of Hepatitis C: Fibromyalgia by Alan Franciscus/HCV Advocate



The Hepatitis C Connection – Fibromyalgia

There is a possible association between hepatitis C (HCV) and Fibromyalgia (FM).  Hepatitis C and FM share many symptoms such as fatigue, depression, cognitive issues, muscle and joint pain. The exact association has not been discovered, but many experts believe that HCV may act as a trigger to the onset of FM. Of interest, one study found that people with FM and HCV exhibit symptoms such as inflammation around joints, bursa (sac containing fluid for lubrication of joints) and/or tendons, and vasculitis (blood or lymph vessel inflammation), that are not seen in FM in people without HCV.

The prevalence of FM in people with hepatitis C has been found to be much higher than in the general population – 15% to 19% compared to approximately 2% of FM seen in the general U.S. population.

Of note, FM is believed to be triggered by viral infections.  If we can test, treat and cure hepatitis C as early as possible there is a very real possibility that we can prevent many of these extrahepatic manifestations such as FM.

More information – Fibromyalgia

Foreword: It is estimated that more than 5 million people in the United States have FM. FM is a condition (rather than a disease) which causes widespread muscle pain, fatigue and multiple tender points in specific parts of the body. The pain is felt all over the body and it been described as aching muscles and burning tissues. The exact cause of FM is not known, but some experts believe that it may be caused by the malfunction of certain neurotransmitters in the brain and spinal cord. FM affects people differently and the symptoms or severity of symptoms can’t be predicted. FM is more common in women than in men. FM is a chronic condition – that is, it is a life-long condition for most people, but it is not a progressive disease and it is not thought to shorten normal life expectancy. It can, however, greatly reduce the quality of life of those who suffer from this condition.

FM is sometimes referred to as an arthritis-related condition, but FM is not considered a true form of arthritis because it does not cause inflammation or damage to the muscles, joints or other tissues involved. It is, however, considered a rheumatic condition that impairs the joints and/or soft tissues and causes chronic pain.

Symptoms: The symptoms of FM vary from person to person. The most common symptoms and conditions associated with FM include:

  • Fatigue that can range from mild to severe
  • Sleep disturbances such as such as trouble falling asleep, staying asleep and/or waking up feeling exhausted (non-refreshing or non-restorative sleep)
  • Restless legs syndrome, a disorder of the nervous system that affects sensation and movement in the legs and causes a strong urge to move the legs. Restless legs syndrome can also interfere with sleep since the symptoms are usually worse at night
  • Stiffness when waking or after remaining in one position for a prolonged period of time
  • Irritable bowel syndrome, a condition characterized by stomach pain and bloating and frequently alternating constipation and diarrhea in the absence of any disease
  • FM Fog” symptoms, including difficulty concentrating, forgetfulness and mixing up words when speaking or reading (similar to HCV “Brain Fog”)
  • Headaches that are usually caused by tight neck and shoulder muscles or from the pain associated with FM
  • Hyper-sensitivity to light, noise, touch, and temperature
  • Hypotension and reduced heart rate
  • Numbness or tingling in the extremities (legs and arms)
  • Anxiety, depression, and irritability due to pain, isolation and the unpredictability of the symptoms
  • Painful menstrual periods in the absence of an infection
  • Light-headedness and balance problems such as trouble with balance while standing and difficulty in visual tracking
  • Pain described as burning or aching from knots in various muscle and tissue areas that can vary in intensity from mild to severe
  • Hyper sensitivity to pain—in other words, a person with FM might feel more severe pain than normal


Causes of Fibromyalgia: The exact cause of FM has not been established, but it is believed that FM may be triggered by a physically or emotionally stressful or traumatic event, repetitive injuries, illness (such as HCV), rheumatoid arthritis or by an autoimmune disease. FM may also be influenced by a person’s genes and may run in families. There is evidence that FM is caused from one or more of the triggers above and that it affects the way that pain is processed by the central nervous system. In the past, it was believed that FM was a disease of the muscles and soft tissues, but researchers have documented brain and central nervous system abnormalities. Another theory is that people with FM may have a gene that causes them to react strongly to certain stimuli that others might not perceive as painful.

 Diagnosis: Currently, there is not a simple blood test for diagnosing FM. Before a diagnosis of FM other conditions should be ruled out especially conditions that have similar symptoms. If a physician is not well-versed in FM the diagnosis may be overlooked.

Physicians who are familiar with FM can make a diagnosis based on criteria established by the American College of Rheumatology (ACR) after ruling out any other conditions or diseases:

  • Widespread pain (right and left side body pain above and below the waist) that lasts for more than 3 months
  • A number of painful areas out of 19 parts of the body and based on the severity of symptoms such as fatigue, waking unrefreshed, memory and thought problems


Management: There is no cure for FM, but there are many strategies to manage the condition.  This may include medications to control the pain and wellness strategies to help to make the person with FM more comfortable. A comprehensive approach with many different health providers (doctor, physical therapist and others) seems to work best – an approach that includes the person suffering from FM is a key element in successfully managing and treating FM.


There are no drugs to cure FM, but there are many strategies that can help to manage some aspects of FM.

Over-the-Counter (OTC) Medications: OTC pain relievers such as acetaminophen (Tylenol), aspirin, and ibuprofen.  But do not take too much because even these can cause liver, kidney, bleeding problems and other issues.  Talk your medical provider to make sure you are staying within the safe limits of these medications.

Pain Medications:  pain medications such as opioids can be used to treat severe pain but long-term use should be avoided because of the high risk of physical and psychological dependency. Talk with your medical provider about pain medications that have a lower risk of addiction.

Approved Medications:

There are currently three medications approved by the Food and Drug Administration (FDA) to treat FM—Lyrica, Cymbalta, and Savella.

Pregabalin (brand name Lyrica): In the studies submitted to the FDA the improvement in pain by drug dose reported was 68.1% (300 mg dose), 77.8% (450 mg dose), 66.1% (600 mg dose), and 47.5% in the group that received the placebo medication. Some patients reported a decrease of pain within the first week of treatment. The most common side effects reported were blurred vision, constipation, increased weight, dizziness, feeling sleepy and headache. The side effects were generally reported as mild to moderate. The recommended dose of Lyrica is 300 to 450 mg/day. Pregabalin is also approved to treat partial seizures, pain following the rash of shingles and pain associated with diabetic nerve damage (diabetic neuropathy).

Duloxetine HCL (Brand name Cymbalta): The FDA approved Cymbalta for the treatment of FM. In the clinical studies submitted to the FDA, 51% to 55% of patients receiving Cymbalta had a 30% improvement in pain and 65% to 66% reported feeling better. The most common side effects of Cymbalta include nausea, dry mouth, sleepiness, and constipation. Cymbalta is a reuptake inhibitor of serotonin and norepinephrine that is theorized to treat depression and pain by increasing the activity of serotonin and norepinephrine in the central nervous system. The recommended dose of Cymbalta is 60 mg daily. Cymbalta is also FDA approved in adults for the treatment of a major depressive disorder, the acute treatment of generalized anxiety disorder, and the management of diabetic peripheral neuropathic pain.  Cymbalta may cause liver problems so liver functions should be monitored especially at the beginning of treatment.

Milnacipran HCI (brand name Savella): In two large clinical trials, patients receiving Savella reported a 30% reduction in pain compared to what they experienced before they started taking Savella. The most common side effects reported were nausea, constipation, hot flush, hyperhidrosis (abnormal sweating), vomiting, palpitations, increased heart rate, dry mouth, and hypertension. Savella is thought to work by blocking certain brain neurotransmitters—norepinephrine and serotonin.

Milnacipran HCI (Savella) is not generally recommended for people with liver disease.

There are other antidepressants and pain medications that are not approved by the FDA to manage and treat FM, but they may be prescribed “off-label” to treat FM. Consult with a medical provider for diagnosis, management, and treatment.

Exercise: Research has found that aerobic and flexibility exercises are some of the best tools for managing FM. Try gentle exercise like walking. Gentle stretching is also helpful. New research is examining strength training exercises. Physical therapy has also been found to improve the symptoms.

Sleep: Getting the right type and enough sleep is very important. This can be difficult for people with FM since the symptoms of FM can interfere with amount and quality of sleep. Talk to your medical provider about medications to treat sleep disorders, pain management, and restless legs syndrome to help restore the quality of sleep.

Stress: Stress can trigger or worsen the symptoms of FM.  Stress management is another important tool that a person with FM can use to manage their symptoms. Try relaxation, prayer, meditation and other techniques to lower stress.

Work Place Adjustments:  It may be helpful to find out if an employer allows for flexible work schedules, and improving the physical work environment with ergonomically correct equipment.  This may include adjustments to chairs, desks and computer monitors. If you are unable to work you may be eligible for disability benefits from Social Security or from private disability insurance. People with FM have work place protections. Contact the Americans with Disability office at 1-800-949-4232 for more information.

Complementary Medicine:  There are many practices that can help reduce some of the symptoms of FM and to help relieve the stress of living with a chronic condition including:

  • Acupuncture:a practice to stimulate and restore energy flows through the body by inserting special small slender needles into certain points in the body
  • Acupressure:the same principle as acupuncture, but finger pressure is used instead of needles
  • Prayer and healing practices
  • Deep breathing techniques
  • Biofeedback:a technique that a person learns to control bodily functions such as heart rate, blood pressure, and pain
  • Relaxation techniques:meditation and healing practices
  • Massage
  • Yoga, tai chi, and Qigong


Support Groups: People with FM, like people with HCV, can greatly benefit from professional counseling and/or a support group to deal with the emotional and physical realities of living with FM.

Recommended Resources:

National FM Association (NFA)


American College of Rheumatology


Patients Assistance Programs

Hep C Medications Blog


This article is published with permission by Alan Franciscus and HCV Advocate.


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4 Responses to Extrahepatic Manifestations of Hepatitis C: Fibromyalgia by Alan Franciscus/HCV Advocate

  1. Richard s. December 6, 2017 at 9:51 am #

    Connie, a very interesting article. I remember asking one of my doctors many years ago about FM, because my ex pastors wife had a very bad case of FM. He thought that it was a mental disorder, so much for his opinion. She suffered greatly. Although I feel bad for those with FM, I am glad to see that it is a real disease and hopefully one day there will be a cure. God bless all the hep c warriors with good health and a closer relationship with the Lord Jesus Christ. His bondservant, Richard.

    • Connie M December 6, 2017 at 10:09 am #

      Hi Richard,
      Thank you for sharing. Fibromyalgia is a real condition for sure. I know I’ve heard of other doctor’s in the past did not know much about it and brushed it off. More and more is being learned about it. There are some medications out now that do help with symptoms. I believe with Hepatitis patients they are continuing to learn about other conditions that can be related and watch out for. Again, this takes being proactive on the patient’s part to be persistent in good health practices as well as seeking help medically. We must never give up!

      Blessings my friend,

  2. Suzanne December 8, 2017 at 10:57 am #

    Good Morning,
    I had a rough week with brain fog, shaking and other symptoms that I get from time to time. I grabbed my Lactulose and that helps some but doesn’t control the other symptoms and just ride it out. The shakiness is subsiding so should be back to normal soon. I don’t follow the instructions on Lactulose as my doctor knows just chug it until the results are obtained. This to will pass.

    Connie, what an interesting article. I cannot imagine having anything but Cirrhosis; anything on top of that would be a lot for one person. I have often wondered if I had that with having some of the symptoms you listed but the doctor said no my pain is strictly arthritis.

    I hope everyone is well and sending John M. a special get well greeting and you are being prayed for.; God has really been busy with you. May God give you even more blessings as you recover..

    In Christ,


    • Connie M December 11, 2017 at 11:20 am #

      Hi Suzanne,
      Thank you for sharing. I’m sorry you’ve been experiencing some rough episodes. I pray this passes quickly. I know you’re turbo tennis shoes have probably been smokin’ so rest up.

      Praying you will feel better very quickly.

      Blessings my friend,

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